Team research topics:

Our team studies the inflammatory mechanisms that lead to neuronal degeneration and vascular remodeling in age-related macular disease, diabetic retinopathy, and non-infectious uveitis.

Research areas

• Determine inflammatory state of immune cells in cohorts of AMD, DR and NIU patients
• Develop AMD models based on the consequences of genetic risk factors and clinical findings
• Decipher how the cholinergic anti-inflammatory pathway and the inflammatory reflex control phagocyte mobilization and function in retinal inflammation
• Study how systemic plasma signals determine macroglia polarization
• Determine similarities and differences in MP and microglia polarization in DR, AMD, and NIU using deep immunophenotyping

Main techniques used:

Address :
17 Rue Moreau, 75012, Paris

Team leader :
Florian Sennlaub
Name of co-team leader :

Administrative Contact Name :
Dominqiue Santiard-Baron

Website : Cliquez ici
Key words : #Neuroinflammation #neurodégénérescence #privilège #immun #maladie #rétinienne #phagocyte #mononucléaire Neuroinflammation #neurodegeneration #immune #privilege #retinal #disease #mononuclear #phagocyte