Inflammation and Immunology in Retinal Diseases


Axe 1 : Génomique, cellules humaines, reprogrammation et neuro-organoïdes

Axe 2 : Approches quantitatives à l'exploration du comportement et de la cognition

Team research topics:

The retina, is considered “immune privileged”, meaning that innate and adaptive immune responses are dampened or suppressed, likely because it is particularly vulnerable to immunopathogenic collateral damage, as it has very limited regenerative capacities. Nevertheless, this immune privilege is relative and in diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR), we observe the protracted accumulation of pathogenic mononuclear phagocytes (MPs). More dramatically, in non-infectious autoimmune uveitis (NIU, accounting for about 10% of all cases of total blindness), tissue damage is associated with the presence of autoreactive T-cells against retinal antigens, with secondary infiltration of pro-inflammatory MPs that are largely responsible for the tissue destruction that characterize this pathology

Main techniques used:

The research team S14 is the only laboratory in France, and one of the rare teams in Europe and worldwide, to specifically address immunological aspects of these common blinding deseases using donor and patients' tissues (eyes/blood samples etc.) and preclinical models in vivo and in vitro models.

Address :
17 Rue Moreau, 75012, Paris

Team leader :
Florian Sennlaub
Name of co-team leader :

Administrative Contact Name :

Website : Cliquez ici
Key words : #Neuroinflammation #neurodégénérescence #privilège #immun #maladie #rétinienne #phagocyte #mononucléaire Neuroinflammation #neurodegeneration #immune #privilege #retinal #disease #mononuclear #phagocyte
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