Objective:

Differentiation of human iPSC cells allows the study of cellular processes or genes specific to humans. This approach complements animal studies and reduces their use. It also provides access to pathological tissues to study the etiology of diseases and to test therapeutic approaches in preclinical human models. Finally, this method allows to address aspects of multigenic diseases that are difficult to model in animals, such as certain psychiatric diseases. The goal of this initiative is to develop a regional platform to promote academic and industrial access to human in vitro models, in particular to organoids of different regions of the nervous system for basic and preclinical studies.

Comity:

• Mme Stéphanie Bigou, ICM (Comité de pilotage)
• Cécile Charrier, ENS (Comité de pilotage)
• Mme Lydia Danglot, IPNP (Comité de pilotage)
• Mr Vincent El Ghouzzi, NeuroDiderot (Comité de pilotage)
• Mr Raphael Etournay, Institut Pasteur
• Mme Fiona Francis
• Mr Olivier Goureau, IdV (Comité de pilotage, suppléant)
• Mme Simona Gribaudo, IFM (Comité de pilotage, suppléant)
• Mr Bassem Hassan, ICM
• Mme Sophie Lebon, NeuroDiderot (Comité de pilotage, suppléant)
• Mr Uwe Maskos, Institut Pasteur
• Mr Stéphane Nedelec, IFM (Comité de pilotage)
• Mme Julie Nguyen (Comité de pilotage, suppléant)
• Mr Serge Picaud, IdV
• Mr Philippe Ravassard, ICM (Comité de pilotage)
• Mr François Rouyer, NeuroPSI
• Mme Amélie Slembrouck, IdV (Comité de pilotage)