Team research topics:

The main objectives of the GCRN team are to study the consequences of in vivo alterations of specific neurotransmitter systems on brain homeostasis and functioning (physiology, plasticity, and behavior) and, conversely, to understand the effects of ageing and neurodegenerative conditions, on the metabolism and mechanisms of synaptic activity. Our experimental model is Drosophila, which is widely used internationally to study neurotransmission and neurodegenerative mechanisms in a living animal. The team's objectives have evolved in recent years to address more specifically the relation between the dopamine system, locomotor activity and stress resistance, with a particular emphasis on Parkinson’s disease-related deteriorations. Our aim is also to discover potential therapeutic strategies by identifying new synaptic proteins and endogenous pathways involved in neuroprotection.

   

Main techniques used:

Drosophila genetics (mutants, transgenesis, RNA interference, gene expression), molecular biology, proteomics and metabolomics, neurotransmitter assays, brain imaging, behavioral analysis.

Address :
ESPCI-CNRS 10 rue Vauquelin 75005 Paris

Team leader :
Serge Birman
Name of co-team leader :

Administrative Contact Name :


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Key words : #Transmission #synaptique #neurones #dopaminergiques #interactions #glie-neurones #Parkinson #Synaptic #transmission #dopaminergic #neurons #glia-neuron #Drosophila