Team research topics:

We are focusing our research on the procedural learning, which corresponds to the acquisition of skills through repeated performance, such as biking. Cortex-basal ganglia loops are involved in the adaptive control of behavior and are the main substrate for procedural learning. We are dissecting the processing of information in cortico/thalamo-basal ganglia circuits, from sub-cellular to neural network levels in control and pathophysiology (Parkinson’s disease).

Our main focus is about the role of the striatum, the primary input nucleus of basal ganglia, and the cortico- and thalamo-striatal long-term plasticity maps which provides a fundamental mechanism for the function of basal ganglia in action selection and procedural learning. We are investigating plasticity maps and signalling pathways in steps necessary for the building of   procedural learning: from one-shot learning to goal-directed behaviour and habit formation, and their flexibility.

 

Main techniques used:

In vivo and in vitro electrophysiology, 2-photon imaging, optogenetics and behavioural tasks.

Address :
11, place Marcelin-Berthelot 75231 Paris Cedex 05

Team leader :
Laurent Venance
Name of co-team leader :

Administrative Contact Name :


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