Study of asymmetric division, a process that generates cellular diversity, in vertebrates and invertebrates.

Goal

To understand how neural stem cells choose between proliferation and differentiation during development of the nervous system.

Current Projects

 How is Mib1 recruited to the Golgi apparatus, and what are the molecular partners that regulate the Mib1 traffic between Golgi and centriolar satellites to control fate choices? A known role of Mib1 is to modify Dll1, a Notch ligand, at the cell membrane: therefore we think likely that Mib1 is essentially active in this location, while Golgi and centriolar satellites essentially fulfill a role of storage and routing. When and how does Mib1 transit between satellites and the plasma membrane?

Answering all these questions requires high-resolution tracking of the sub-cellular localization of Mib1 over time, both during cell cycle progression and developmental time. It is also necessary to be able to purify Mib1 to identify its specific binding partners in different cellular compartments. We are developing the tools to respond to these questions.

Address :
46 Rue d'Ulm, 75005, Paris

Team leader :
Morin Xavier
Name of co-team leader :

Administrative Contact Name :
VILLA Tommaso

Website : Cliquez ici
Key words : #cellules souches neurales#signalisation#imagerie en temps réel#chromatine # #neural stem cells#signaling#real-time imaging#chromatin#