We explore the cellular and molecular mechanisms involved in the transport of mRNAs in neurons. This transport, along with the local translation of mRNAs in the axon, far away from the cell body, ensures precise spatiotemporal control of the axonal proteome, essential for axon growth and synapse formation. Disruptions of this process are frequently associated with neurodevelopmental and neurodegenerative diseases.

Our goal is to better understand the mechanisms involved in the formation and long-distance transport in the axon of ribonucleoprotein (RNP) granules, which contain mRNAs and RNA-binding proteins. Using a multidisciplinary approach that combines molecular and cellular biology, in utero electroporation, and imaging, we aim to address the following questions:

• How do inter-organelle interactions regulate the formation of RNP granules?
• What are the mechanisms controlling the specificity of mRNA incorporation into RNP granules?
• What factors are involved in regulating the dynamics of RNP transport and their local translation?

Address :
Cassan, Bat. A, Campus Pierre et Marie Curie 7-9 quai Saint Bernard 75005 Paris

Team leader :
BROIX Loic
Name of co-team leader :

Administrative Contact Name :
Alix Rousselet

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