We intend to identify alterations in enzymatic and metabolic pathways and design tools to alleviate pathological adaptations. We primarily analyze these mechanisms within the striatum, a key target structure of addictive substances and the most vulnerable brain region to neurodegeneration in HD. Using a combination of multidisciplinary approaches ranging from a molecular standpoint, to imaging and behavioral studies in rodents, our overall goals are:

·To understand how signal transduction within basal ganglia can govern neuronal adaptations and long-term behavioral changes.

·To study how these pathways, by regulating epigenetic and genetic responses, can control persistent neuronal and behavioral alterations induced by drugs of abuse or striatal dysfunction in HD.

·To identify, from the plasma membrane to the nucleus, therapeutic targets and overcome dysfunction encountered in diseases such as psychiatric disorders and HD.

Address :
Cassan, Bat. A, Campus Pierre et Marie Curie 7-9 quai Saint Bernard 75005 Paris

Team leader :
VANHOUTTE Peter
Name of co-team leader :

Administrative Contact Name :
Alix Rousselet

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