Bring together expertise in gene regulation, rare Mendelian diseases, signaling pathways, cell and developmental biology and therapeutic approaches.

Our research is based on animal models and primary cells or iPSCs from patients, and benefits from partnerships with pharmaceutical companies.

Our goals are :

1. to develop technologies for generation of zebrafish models of human disease-causing mutations by precise genome editing,
2. to generate animal and cellular models for human skeletal diseases caused by FGF signaling deregulation, for the development of novel therapeutic approaches (several preclinical trials are ongoing),
3. to develop 2D and 3D IPS cell-based models to explore the role of primary cilia in the development of the human brain,
4. to dissect the molecular network, including transcriptional and post-transcriptional regulation, governing enteric and peripheral nervous system differentiation and maintenance.