Team research theme:

Over the last decade and using state-of-the-art genetic and genomics technologies, our group has characterized numerous chromosomal anomalies and disease-causing mutations responsible for developmental brain disorders (DBD) with a specific emphasis on the cerebellar development. Our research is dedicated to the identification of additional genetic causes of DBD including oligogenic mechanisms and involvement of the non-coding genome. Then, we aim to evaluate the functional impact of newly identified genomic variants with several complementary approaches based on CRISPR-Cas9 genome editing system in human neural stem cells and zebrafish.

Main techniques and approaches used:

• Human whole exome or genome sequence analysis
• Modeling using human induced stem cells and neuronal differentiation protocol (2D)
  
• Development of the cerebellar organoid model
  
• Modeling with zebrafish
  
• Genome editing in cells and fish
  

Address :
24, Bd de Montparnasse - 75015 Paris

Team leader :
Vincent Cantagrel
Name of co-team leader :

Administrative Contact Name :


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Key words : #Génétique #Humain #Neurodéveloppement # Cervelet #iPS #Poisson-zèbre #Human #Genetics #Neurodevelopment #Cerebellum #Zebrafish