Team research theme:

Our working hypothesis is that neuronal dysfunctions and cell death occurring in neurodegenerative diseases arise not only from intrinsic neuronal impairments, but also from the convergence of dysfunctions and damages in several cell types and in specific areas of the brain. This includes synaptic interactions between the most vulnerable neurons within the networks, as well as functional interactions between neurons and neighboring glial cells such as astrocytes or microglia. In order to question the respective role of specific cell populations, we are developing innovative in cellulo and in vivo models of Parkinson's and Alzheimer's diseases using viral vectors. We use the models thus created to understand the mechanisms of neurodegenerative diseases, and to design innovative gene and cell therapies.

Main techniques and approaches used:  

In vivo gene transfer; Human iPS cells; Mouse models of neurodegenerative diseases; AAV and lentiviral vectors; Quantitative histology and morphometry; Confocal microscopy; Real-time cellular imaging; High-throughput screening; Transcriptomics.

Address :
18 route du Panorama, 92260, Fontenay-aux-Roses

Team leader :
Alexis Bemelmans
Name of co-team leader :
Anselme Perrier
Administrative Contact Name :


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Key words : #Maladies #Neurodégénératives #Cellules #Gliales #Transgert #Gènes #iPS #Neurodegenerative #Diseases #Glial #Cell #Gene #Transfert