We combine behavioral analysis of mouse models of neurological disorders with investigations at circuit level and in cultured neurons. Mechanisms are analyzed by RNA-seq and manipulated using molecular biology tools.

The importin family of nuclear import factors have pivotal roles in the subcellular transport of proteins from the cytoplasm and the synapse to the nucleus. While huge efforts helped to decipher the basic elements and properties of the nuclear transport, including the importin families of nuclear transport carriers, little attention has been paid to the roles of importins in the regulation of CNS functions. In recent years, we and others have showed that importins have pivotal roles in the neuronal and nuclear transport of macromolecules during synaptic plasticity, survival, regeneration, and key functions such as anxiety and chronic pain.

The goal of our team is:

1. to determine the fundamental roles of importins in neuronal functions,
2. to modulate these pathways in rare and devastating neurogenetic disorders such as Rett and MeCP2 duplication syndromes, 
3. and to optimize molecular tools to decipher the mechanistic rules of importin-mediated transport and modulate them in pathological contexts.
   

Address :
Université Paris Cité 45 Rue des Saints-Pères 75270 Paris

Team leader :
Nicolas Panayotis
Name of co-team leader :

Administrative Contact Name :


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Key words : #Transport #nucléaire #Syndrome #Rett #Modeles #souris #Neurobiologie #Moléculaire #Nuclear #transport #Rett #syndrome #MeCP2 #Mouse #Models #Molecular #Neurobiology