Team research team:

Our research primarily focus on the development of the spinal cord and hindbrain.

Our goals are to:

1. Elucidate the dynamics of signaling pathways and transcriptional programs that orchestrate neural tube morphogenesis and drive the emergence of the diverse progenitor and neuronal populations that form sensory and motor circuits.
2. Decipher how rare genetic mutations disrupt these developmental processes, leading to neural tube defects, pediatric cancers—particularly rhabdomyosarcoma—and motor neuron diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis.

Address :
15 Rue Hélène Brion 75013 Paris

Team leader :
Stephane Nedelec
Name of co-team leader :
Vanessa Ribes
Administrative Contact Name :


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Key words : #embryo#spinal cord#organoids#human and murine pluripotent stem cell#iPSC# development# signaling pathways# transcription factors# cell fates