Team research team:

Our laboratory studies the molecular and cellular basis of normal and pathological human embryogenesis and organogenesis. We seek to decipher the principles that govern the specification and organization of neuronal diversity, and how genetic mutations disrupt these events to cause disease.

 We are developing targeted differentiations of hPSCs into specific neuronal subtypes, spinal or trunk organoids to study signal transduction pathways and genetic networks that couple cell fate and tissue morphogenesis to form distinct sensory-motor circuits along the body axis. In parallel, we use the in vitro models resulting from these developmental studies to investigate in collaborative studies the basis of neura tube defects and motor neuron diseases; in particular, a juvenile form of amyotrophic lateral sclerosis (ALS) and pediatric motor neuron diseases called spinal muscular atrophies (SMA), especially rare forms called SMALED.

 

Main techniques used:

Human pluripotent stem cells, Organoids, microfluidics, transcriptomics, live cell imaging, histology.

Address :
17 Rue du Fer à Moulin 75005 Paris

Team leader :
Stephane Nedelec
Name of co-team leader :

Administrative Contact Name :


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Key words : #Neurodéveloppement #organoides #maladies #neurones #moteurs #système #nerveux #Neurodevelopment #organoids #diseases #motor #neurons #nervous #system