Team research topics:

The cerebral cortex is crucial for basic and sophisticated cognitive functions, such as sensory perception sensory perception, memory, language and abstract thought.

Diversity is a hallmark of the cerebral cortex. The different functional cortical areas are home to heterogeneous cortical networks formed by a spectacular diversity of neuronal subtypes. Even the multitude of synapses connecting different neurons have specific molecular, physiological and plastic fingerprints. How do cortical computations emerge from such multiscale diversity and produce specific behaviors?

We are studying how connections between different types of neurons, and how the properties and plasticity of these connections, underpin the orchestration of diverse network activities relevant to cognition. We are also investigating how specific alterations in cortical circuits may contribute to the emergence of different brain diseases.

 

Main techniques used :

The laboratory combines a variety of experimental approaches, including ex vivo and in vivo electrophysiology, two-photon imaging, behavioral analysis when exploring specific cortical circuits, as well as anatomy, cell and molecular biology.

Address :
Hôpital Pitié-Salpêtrière 47 bd de l’Hôpital 75013 Paris

Team leader :
Alberto Bacci
Name of co-team leader :

Administrative Contact Name :


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Key words : #Circuits #corticaux #interneurones #inhibition #plasticité #transmission #synaptique #Cortical #circuits #interneurons #inhibition #plasticity #synaptic #transmission