Genetic mouse models, multiscale imaging modalities including electron microscopy, “omics approaches including bulk & single cell RNAseq and proteomics, brain MRI, genetic interaction studies in the mouse.

Cerebral small vessel diseases (SVD) account for ~25% of ischemic strokes, ~ 90% of intracerebral hemorrhages (ICH) and are a leading cause of cognitive decline and disability. Our limited understanding of the pathogenesis of SVD is a major obstacle to the development of treatment. Our team studies molecular mechanisms underlying functional or structural lesions of small cerebral vessels as well as mechanisms by which lesions of these small vessels cause ischemia or cerebral hemorrhages. We use, as experimental models, monogenic forms of SVD which clinical features are largely indistinguishable from the most common sporadic forms of SVD, in particular, CADASIL, an ischemic form of SVD caused by highly stereotyped mutations of the Notch3 receptor, and the collagen IV disease, an hemorrhagic form of SVD caused by highly stereotyped mutations in the alpha1 or alpha 2 chains of collagen IV.

Address :
INSERM U1266, 102-108 rue de la santé, 75014, Paris

Team leader :
Anne Joutel
Name of co-team leader :

Administrative Contact Name :


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Key words : #Maladies #vaisseaux #cérébraux #uniténeurovasculaire, #cellules #musculaires #lisses #matrisome #Cerebral #small #vessel #diseases #neurovascularunit #smooth #musclecells #matrisome