We use cellular, biochemical and behavioral approaches to characterize novel mouse models of these conditions to ascertain if they can phenocopy the human disease, and to study, through genotype reversion, if certain phenotypes are reversible. We use qua

Many kinases have been linked to monogenic ASD-subtypes, however, their role in the mechanisms underlying disease etiology is not well understood. ASDs, like other types of neuro-psychiatric disorders, are poised to be associated with deficiencies in specific cell types, neurons, or glia, in the brain, as suggested by single cell RNAseq. However, the proteome, let alone the phosphoproteome have not been well studied. We are primarily interested in a newly described ASD conditions, OCNDS, linked to variants in genes encoding the kinase CK2α.    

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INSERM U1266, 102-108 rue de la santé, 75014, Paris

Team leader :
Heike Rebholz
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Key words : #Kinases #signalisation #autisme #troubles #développement #neurologique #protéomique #Signaling #autism #neurodevelopmental #disorders #proteomics