Plasticity of central auditory circuits

Institut de l'Audition

Axe 1 : Génomique, cellules humaines, reprogrammation et neuro-organoïdes

Axe 2 : Approches quantitatives à l'exploration du comportement et de la cognition

In vitro and In Vivo electrophysiology, animal behavior, immmunostaining and confocal imaging, genetic models, single cell transcriptomics

Inherited hearing disorders mostly involve gene defects in the auditory peripheral sensory organ, the cochlea. However, peripheral deafness may be associated with central auditory dysfunctions and may extend well beyond the auditory system itself, as a consequence of alterations to the encoded sensory inputs or involvement of the causal deafness genes in the development and/or functioning of central auditory circuits.

The PCAC team composed of around 10 scientists focuses on three main research axis:

  1. the molecular deciphering of the cochlea by single cell transcriptomics,
  2. Central auditory deficits in genetic forms of deafness, and
  3. the role of the cerebrovascular system in the link between hearing loss and dementia.

Address :
63 rue de Charenton, 75012, Paris

Team leader :
Nicolas Michalski
Name of co-team leader :

Administrative Contact Name :

Website : Cliquez ici
Key words : #Circuits #auditifs #modèles #génétiques #comportement #plasticité #Auditory #circuits #genetic #models #behavior #plasticity
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