Characterization of the cellular and molecular mechanisms underlying the establishment of the spatial organization of the auditory organ-control of the spatial organization of inner ear organoids

Our aim is to use a multiscale approach to characterize the cellular and molecular mechanisms that shape the cochlea, during the first stages of development, into a spatially distributed frequency analyzer. The deciphering of these mechanisms is of major interest both in terms of fundamental research and in terms of potential medical applications. The team is thus working on two complementary research projects aiming to decipher the cellular and molecular mechanisms underlying the development of the organ of Corti, and using stem cells to generate inner ear organoids reproducing the spatial organization of the cochlea in vivo or in culture. These organoids will be a very promising tool for the development of auditory therapies, as they make it possible to model certain hearing problems in a personalized manner at low cost.

Projects

Characterization of the cellular and molecular mechanisms underlying the establishment of the spatial organization of the auditory organ

Organoid-on-chip: control of the spatial organization of inner ear organoids

Address :
63 rue de Charenton, 75012, Paris

Team leader :
Raphaël Etournay
Name of co-team leader :

Administrative Contact Name :


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Key words : #Cellules #souches #organoïdes #oreille #interne #auto-organisation#tissus #biophysique #Stem #cells #inner #ear #organoids #tissue #self-organization #biophysics