Team research topics:

How is energy metabolism in brain tissues (neurons and glia) modified by experience and how does It In turn Impact memory formation? We follow several axes of Investigation linked to this central question:

• Metabolic role of glial cells in the regulation of memory.

• Functional plasticity of neuronal mitochondria network underlying memory.

• Importance of ROS signaling for long-term memory formation.

Our research Is performed In Drosophila, as this species features a unique combination of experimentally-tractable memory behavior that are well-characterized at the cellular and circuit levels, and a geneti toolbox allowing cell-specific and time-controlled In vivo manipulation of any metabolic biochemical pathway.These assets enable the description of the timecourse of learning-Induced metabolic regulations, and allow us to establish causal relationships between metabolic events In neurons or In glial cells with specific properties of the memory observed at the behavioral level.

   

Main techniques used :

To study how the brain processes and stores external information, we use a multi-level approach, from network to circuit, cellular and synaptic analyses. We use opto- and chemogenetics, whole-brain network analysis using graph theory, in vivo imaging and in vivo electrophysiology.

Address :
ESPCI-CNRS 10 rue Vauquelin 75005 Paris

Team leader :
Thomas Preat
Name of co-team leader :
Pierre-Yves Plaçais
Administrative Contact Name :


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Key words : #Mémoire #Métabolisme #Interaction #neurones#glie #Espèces #réactives #oxygène #Drosophile #Memory #Metabolism #Glia #neuron #interaction #ROS #Drosophila