Mechanisms underlying social and appetitive memory

Our goal is to better understand how area CA2 is incorporated into the hippocampal circuit and under which circumstances this region is most active. Our team currently has a cutting-edge set of tools that allows us to examine the circuitry and physiology of the interneurons and pyramidal cells in area CA2 and the hypothalamus in adult mice. We routinely use electrophysiology, optogenetics and pharmacogenetics to selectively excite or silence CA2 pyramidal neurons. With these methods, our team has discovered unique plasticities of inhibitory transmission that occurs in area CA2 (Piskorowski and Chevaleyre, 2013; Loisy et al, Neuron 2022).

Main technical:

Electrophysiology, optogenetics, pharmacogenetics.

Address :
Cassan, Bat. A, Campus Pierre et Marie Curie 7-9 quai Saint Bernard 75005 Paris

Team leader :
Rebecca Piskorowski
Name of co-team leader :

Administrative Contact Name :
Alix Rousselet

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