Team research topics:

The team is interested in neurovascular interactions in the nervous system, both central and peripheral. In particular, we study perivascular macrophages (PVMs) and cerebral physiopathology.

We have identified that PVMs expressing the lymphatic marker Lyve-1 are present in the perivascular space, between the vessels and the astrocytic feet, and that they exert a function of drainage and maintenance of cerebral homeostasis and are spatio-temporally regulated in the adult mouse brain. In Alzheimer's disease, the number of PVMs does not decrease but they stop expressing the Lyve-1 marker, suggesting plasticity. The team is exploring the possibility of reprogramming PVMs as a therapeutic approach, in particular by exploring the heterogeneity of PVMs using spatial transcriptomics and by manipulating/reprogramming them using lyposomes.

  

Main techniques used:

We are using immunolabelling, 3D transparencies and transcriptomics. We also use in vivo loss and gain of function approaches in mouse models. Finally, we use surgical techniques and behavioral tests.

Address :
11, place Marcelin-Berthelot 75231 Paris Cedex 05

Team leader :
Isabelle Brunet
Name of co-team leader :

Administrative Contact Name :


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Key words : #Neurovasculaire #angiogenese #guidage #axonal #neuropathie #macrophages #peri-vasculaires #Neurovascular #angiogenesis #axon #guidance #neuropathy #perivascular #macrophages