In vitro membrane fusion assays, secretomics, proteomics, video-microscopy of secretion, super-resolution microscopy

  Our team studies the dynamics of intracellular membranes in neurons in both normal and pathological contexts. Abnormalities in endosomal or mitochondrial transport are linked to a variety of psychiatric illnesses, including depression and schizophrenia, but also neurodegenerative diseases such as Charcot-Marie-Tooth (CMT), Alzheimer's, Parkinson's and Huntington's disease. This suggests a role for membrane dynamics in the formation and maintenance of the complex morphology of neurons and their contacts. The molecular and cellular principles governing the establishment and maintenance of neuronal morphology and synaptic contacts remain poorly understood. The team's aim is to understand the mechanisms and regulation of membrane trafficking in the context of the developing brain, brain tumors, psychiatric and degenerative diseases (Parkinson's, Alzheimer's). To achieve this, we use cell and molecular biology techniques, and more specifically microscopic, proteomic and biophysical approaches to study membrane dynamics in vitro and in vivo.

Address :
INSERM U1266, 102-108 rue de la santé, 75014, Paris

Team leader :
Thierry Galli
Name of co-team leader :

Administrative Contact Name :


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Key words : #sécrétion #autophagie #mitochondrie #SNARE #autophagy #mitochondria