Stroke is a very common disorder and a major cause of death, disability and dementia worldwide. The aims of our research are to: (i) identify/better define determinants of stroke prognosis, in terms of response to acute treatment, risk of recurrent stroke and other vascular events, and long-term consequences of brain injury, such as functional and motor outcome, post-stroke cognitive decline or depression), and (ii) assess the benefit–risk ratio of therapeutic strategies through randomized clinical trials. We endeavour to answer clinical questions with direct applications in clinical practice. In addition to clinical expertise in stroke allowing for accurate phenotyping (stroke being a highly heterogeneous disorder), our team has expertise in methodology of clinical research and biostatistics. We have also recently engaged into proof-of-principle, mechanistic and translational studies.

Our main current topics are to (i) better understand and address the mechanisms underlying early recanalization, the demise of the ischemic penumbra and functional outcome after acute ischemic stroke; (ii) identify the determinants (and mechanisms) of stroke and optimize preventive therapeutic strategies in patients with some specific causes of stroke such as carotid atherosclerosis, interatrial septal abnormalities or small vessel disease ; (iii) assess the clinical benefit and neural correlates of individually tailored manual dexterity training in stroke patients (using a specific tool developed by the team)