Team research theme :

Immune processes shape neuronal development through the coordinated action of innate and acquired immunity-related molecules. Microglial cells, the brain macrophages, are central players in the sculpting of developing neural networks by immunity. The essential functions of immune processes during the course of brain development are reflected by the increasing number of studies demonstrating that immune dysfunctions and microglial cells play crucial roles in the etiology of major neurodevelopmental disorders, including schizophrenia and autism spectrum disorder.

Our research focusses on two major aspects of neuro-immune interactions during brain development, namely (i) the role of microglial receptors to serotonin, a major neurotransmitter, in shaping maturation of the cerebral cortex and (ii), the role of the immune complement system in synaptic pruning, a process by which excess connections between neurons are eliminated in the juvenile brain.

Main techniques used:

Mouse models, behavioral testing, patch-clamp, optogenetics, in utero electroporation, biphoton imaging, histology, image analysis, RNA sequencing, biochemistry

Address :
17 Rue du Fer à Moulin 75005 Paris

Team leader :
Anne Roumier
Name of co-team leader :
Corentin Le Magueresse
Administrative Contact Name :


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Key words : #microglie #dévelopement #cerveau #synapse #sérotonine #microglia #brain #development #serotonin