Roles of cilia in brain development and pathology

Team research topics:

Multiciliated cells are epithelial cells that line the airways, the oviduct and the brain ventricles. Each of these cells extend multiple (more than 50) long beating cilia producing a constant extracellular flow that clears mucus from the airways, moves ova from the oviducts toward the uterus and propels cerebrospinal fluid (CSF) through the cerebral ventricles. Each beating cilium grows from a modified centriole, also called a basal body. Defects in motile ciliation or cilia number are associated to severe pathologies including neurodevelopmental disorders, irreversible lung failure and sterility by perturbing cilia-based flows.

Main techniques used:

Address :
46 Rue d'Ulm, 75005, Paris

Team leader :
Nathalie Spassky
Name of co-team leader :

Administrative Contact Name :
VILLA Tommaso

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Key words : #bioinformatiques#imagerie avancée#centriole#cellules épendymaires#circuits neuronaux #bioinformatics#advanced imaging#centriole#ependymal cells#neural circuits