In vitro (MEA, patch clamp, LFP) and in vivo (telemetric EcoG, intracerebral multielectrodes) electrophysiology, viral vectors for neuronal transduction, immunocyto/histochemistry, super-resolution imaging, rodent models, postoperative human brain tissues

Team research topics:

Our team aims to elucidate the pathophysiological mechanisms underlying focal epilepsies, which are common in adults and often resistant to conventional antiepileptic drugs. Our goal is to conduct translational research to identify new targets for more precise and effective treatments. To achieve this, we use a multimodal, multi-scale approach in animal models and post-operative human brain samples to comprehensively study epileptic networks and decipher the fundamental mechanisms that contribute to the pathological activity.

Our research projects include studying the functional impact of mutations associated with epileptic encephalopathies, and aim to understand how mutations in the same genes underlie diverse epileptic phenotypes. We also investigate the characteristics  of epileptic networks, with a particular focus on perturbations in neuronal chloride homeostasis, which are associated with different types of epilepsy and may represent new targets for therapeutic intervention.

 

Main techniques used:

In vitro (MEA, patch clamp, LFP) and in vivo (telemetric EcoG, intracerebral multielectrodes) electrophysiology, viral vectors for neuronal transduction, immunocyto/histochemistry, super-resolutive imaging, rodent models, postoperative human brain tissue.

Address :
17 Rue du Fer à Moulin 75005 Paris

Team leader :
Jean-Christophe Poncer
Name of co-team leader :
Sabine Levi
Administrative Contact Name :


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Key words : #Épilepsie #réseauxneuronaux #synapse #tissushumains #modèlesanimaux #Epilepsy #neuronalnetworks #synapse #humantissue #animalmodels