Principal techniques used : cell biology (primary and cell line cultures, in vitro phagocytosis), molecular biology (siRNAs, RT-qPCR…), biochemistry (immunoblots, immunoprecipitations, signaling pathways, functional inhibition, lipids analysis), histolo

Team research topics:

Our team explores various roles of retinal pigment epithelium cells in the overall homeostasis of the retina.

Research projects include the characterization of the circadian elimination of the aged tips of visual photoreceptor outer segments by phagocytosis and its control at the molecular level, the identification of molecular pathways targeted in pathological conditions such as rod-cone dystrophies/retinitis pigmentosa and age-related macular degeneration, and the exploration of therapeutic approaches including using natural molecules.

 

Main techniques used:

Cell biology (primary and line cultures, in vitro phagocytosis), molecular biology (siRNA, RT-qPCR...), biochemistry (immunoblots, immunoprecipitations, signaling pathways, functional inhibition, lipid analysis), histology (immunocyto- and immunohistochemistry, staining, in vivo phagocytosis), visual phenotyping during aging, etc.

Address :
17 Rue Moreau, 75012, Paris

Team leader :
Emeline Nandrot
Name of co-team leader :

Administrative Contact Name :


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Key words : #Dystrophies #rétiniennes #épithélium #pigmentaire #rétinien #vieillissement #métabolisme #rythme #circadien #Retinal #dystrophies #retinal #pigment #epithelium #aging #metabolism #circadian #rhythm