Neuroglial interactions in cerebral physiopathology and pathologie
CIRB
Axe 1 : Génomique, cellules humaines, reprogrammation et neuro-organoïdes
Axe 2 : Approches quantitatives à l'exploration du comportement et de la cognition
Axe 3 : Réseaux neuronaux, modélisation et intelligence artificielle
Electrophysiology, imaging, molecular biology, behavioral analysis, mathematical modeling
Team research topics:
The goal of our team is to determine whether and how the underexplored astrocytes, which are the very abundant non‐neuronal, but yet active cells of the brain, play a direct role in information processing. We particularly explore the molecular modalities and functional outcomes of astrocyte‐neuron interactions in physiological and pathological contexts, such as memory or epilepsy, focusing ex vivo or in vivo on neuronal excitability, synaptic transmission, plasticity, synchronization and cognitive functions.
To do so, we use a multidisciplinary approach combining electrophysiology, imaging, behavioral testing, mathematical modeling and molecular tools targeting selectively astrocytes in situ and in vivo in mice and human tissues.
Main techniques used:
Electrophysiology, imaging, molecular biology, behavioral analysis, mathematical modeling.
11, place Marcelin-Berthelot 75231 Paris Cedex 05
Team leader :
Nathalie Rouach
Name of co-team leader :
Administrative Contact Name :
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Key words : #interactions #neurogliales #transmission #synaptique #plasticity #comportement #Neuroglial #astrocytes #synaptic #transmission #plasticity #behavior