Decision making, Animal behavior (mice): social behavior, gambling, learning, conditionning, reaction time task. Immunohistochemistry, stereotactic surgery, optogenetics, miniscope, naturalistic environment

 Our research is dedicated at the understanding of the neural and neurochemical bases of decision-making, with a special emphasis on the bases of individual variability, in mice. In particular, we focuse on social tasks, in which animals make decisions and organize flexibly social interactions, and a Mouse Gambling Task which triggers adpated decisions in relation with reward probability. We unraveled individual strategies and showed that they rely on regional brain monoamines levels and on the interplay between the prefrontal cortex, the reward system and limbic circuits. We investigate how environmental manipulations of these circuits (exposure to social enrichment, sleep restriction, stress or sweeteners) can trigger, shape or reshape, at different ages of life, decision-making strategies. In addition, using these dedicated behavioral tasks, we aim at discovering individual biological and behavioral markers of vulnerability -or resilience- to pathological states that specifically target prefrontal cortex, limbic or reward system functions.

Address :
Institut des Neurosciences Paris-Saclay (NeuroPSI) Université Paris-Saclay / CNRS Centre CEA Paris-Saclay - Bât. 151 91400 Saclay, France

Team leader :
Sylvie Granon
Name of co-team leader :

Administrative Contact Name :


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Key words : #Comportement #animal #choix #circuits #préfrontaux #variabilité #inter #individuelle #monoamines #Animal #behavior #choice #prefrontal #circuits #individual #variability #monoamines