To achieve our goals, we use a multidisciplinary approach that combines ex vivo and in vivo preparations and uses electrophysiolgy, calcium imaging, optogenetics, chemogenetics and mouse behavior in relevant mouse models.

This team is interested in understanding the roles of neuron-oligodendroglia interactions during postnatal cortical development and in pathological conditions. We investigate how neuronal activity regulates the function of oligodendrocyte (OL) lineage cells and, in turn, how these cells and myelin affects neuronal activity, influencing sensorimotor and cognitive functions. Our first research line is focused on the study of the close relationship of GABAergic interneurons and oligodendrocyte precursor cells (OPCs) in the developing neocortex. We propose that early interneuron-oligodendroglia interactions are crucial to establish the proper execution of complex brain processes, and that cortical impairments in neurodevelopmental and myelin-related disorders are caused, at least in part, by an abnormal interneuron myelination. The second research line seeks to evaluate the role of neuronal activity in promoting myelin regeneration in preclinical models. We study whether and which neuronal signaling mechanisms control the function of OPCs and OLs and whether stimulating neuron-oligodendroglia interactions improves remyelination.

Address :
INSERM U1266, 102-108 rue de la santé, 75014, Paris

Team leader :
Maria Cecilia Angulo
Name of co-team leader :

Administrative Contact Name :


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Key words : #oligodendrocytes #myéline #interneurones #cortex #neurophysiologie #myelin #interneurons #neurophysiology