To achieve our goals, we use a multidisciplinary approach that combines ex vivo and in vivo preparations and uses electrophysiolgy, calcium imaging, optogenetics, chemogenetics and mouse behavior in relevant mouse models.

This team is interested in understanding the roles of neuron-oligodendroglia interactions during postnatal cortical development and in pathological conditions. We investigate how neuronal activity regulates the function of oligodendrocyte (OL) lineage cells and, in turn, how these cells and myelin affects neuronal activity, influencing sensorimotor and cognitive functions. Our first research line is focused on the study of the close relationship of GABAergic interneurons and oligodendrocyte precursor cells (OPCs) in the developing neocortex. We propose that early interneuron-oligodendroglia interactions are crucial to establish the proper execution of complex brain processes, and that cortical impairments in neurodevelopmental and myelin-related disorders are caused, at least in part, by an abnormal interneuron myelination. The second research line seeks to evaluate the role of neuronal activity in promoting myelin regeneration in preclinical models. We study whether and which neuronal signaling mechanisms control the function of OPCs and OLs and whether stimulating neuron-oligodendroglia interactions improves remyelination.

To achieve our goals, we use a multidisciplinary approach that combines ex vivo and in vivo preparations and uses electrophysiology, calcium imaging, optogenetics, chemogenetics and mouse behavior in relevant mouse models.

Major publications during the last 5 years.

Neuronal activity in vivo enhances functional myelin repair. Ortiz FC, Habermacher C, Graciarena M, Houry PY, Nishiyama A, Nait Oumesmar B, Angulo MC. JCI Insight. 2019 Mar 21;5(9):e123434. doi: 10.1172/jci.insight.123434. PMID: 30896448

Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis. Orduz D, Benamer N, Ortolani D, Coppola E, Vigier L, Pierani A, Angulo MC. Nat Commun. 2019 Sep 18;10(1):4249. doi: 10.1038/s41467-019-11904-4. PMID: 31534164

Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring. Riva M*, Genescu I*, Habermacher C*, Orduz D, Ledonne F, Rijli FM, López-Bendito G, Coppola E, Garel S#, Angulo MC#, Pierani A#. Elife. 2019 Dec 31;8:e50503. doi: 10.7554/eLife.50503. PMID: 31891351

Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits. Benamer N, Vidal M, Balia M, Angulo MC. Nat Commun. 2020 Oct 13;11(1):5151. doi: 10.1038/s41467-020-18984-7. PMID: 33051462

A specific GABAergic synapse onto oligodendrocyte precursors does not regulate cortical oligodendrogenesis. Balia M, Benamer N, Angulo MC. Glia. 2017 Nov;65(11):1821-1832. doi: 10.1002/glia.23197. Epub 2017 Aug 10. PMID: 28795438

Address :
INSERM U1266, 102-108 rue de la santé, 75014, Paris

Team leader :
Maria Cecilia Angulo
Name of co-team leader :

Administrative Contact Name :


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Key words : #oligodendrocytes #myéline #interneurones #cortex #neurophysiologie #oligodendrocytes #myelin #interneurons #neurophysiology #cortex