Team research topics:

The DSP team focuses on late and progressive hearing impairment, sometimes accompanied by loss of balance and/or vision, from the mechanisms underlying sensory impairment to potential therapeutic treatments. The team's interdisciplinary approach is based on the use of different models for each disorder (cellular models, total or conditional inactivation in mice, humanized mice, etc.). Analyses cover the properties of the proteins involved in the pathology, their molecular networks, OMIC investigations, imaging, and physiology and behavioral studies of the corresponding animal models.

1. Identify the early mechanisms, and the precise sequence of events at the origin of the disease, which will help to unravel the subtle changes in people with hearing loss,
2. unravel the impact of external factors such as noise exposure or aging on auditory and balance functions, to identify potential protective and/or deleterious factors,
   
3. and evaluate the efficacy of gene therapies (gene replacement and/or gene editing) in preventing, slowing or correcting sensory decline.

 

Main techniques used:

In silico analysis, protein-protein interaction studies, creation and characterization of animal models for visual and/or auditory pathologies, OMIC analyses, confocal imaging and microscopy, super-resolution and electronics of sensory organs, auditory functional measurements, vestibular behavior monitoring, gene therapy (gene supplementation, gene editing).

Address :
63 rue de Charenton, 75012, Paris

Team leader :
Aziz El Amraoui
Name of co-team leader :

Administrative Contact Name :


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Key words : #Audition #équilibre #surdité #cécité #Vieillissement #organes #sens #interactions #gène #environnement #thérapie #génique #Hearing #balance #deafness #lindness #aging #sensory #organs #gene #environment #interactions #gene #therapy