Advancing Sensory Precision Medicine: From Disease Mechanisms to Therapeutic Solutions

Team research topics:

We combine cutting-edge approaches across multiple disciplines—genetics, molecular biology, advanced imaging, electrophysiology, and behavior—to investigate the molecular, cellular, and systems-level mechanisms of hearing, balance, and vision deficits. Our multiscale and integrative phenotyping pipeline enables deep functional and structural profiling of disease models. This allows us to map disease trajectories with exceptional precision and to assess early-stage disruptions that precede irreversible damage.

At the Progressive Sensory Disorders (PSD), a research unit at the Institut de l’Audition, Institut reConnect, center of the Institut Pasteur, we are committed to advancing the frontiers of sensory neuroscience and therapy. Our research addresses the complexity of disorders affecting the inner ear and retina, with a special interest to progressive conditions that often begin postnatally and worsen over time

Three Interconnected Research Aims

We approach sensory disorders through three primary research objectives:

1. Deciphering Disease Mechanisms—From molecular signatures to physiological and behavioral outcomes, we aim to identify the biomarkers and pathways underlying progressive sensory dysfunction. These insights support early diagnosis and targeted interventions.
2. Investigating External Modulators—We study how aging, environmental noise, inflammation, and oxidative stress influence disease onset and progression, identifying modifiable factors that shape patient outcomes.
3. Developing Therapeutic Solutions—Using gene supplementation, mini-genes, dual-AAV systems, and gene editing technologies (e.g., CRISPR), we design and test novel treatments. Our goal is to develop scalable, mutation-specific therapies that restore sensory function and slow or prevent degeneration.

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Address :
63 rue de Charenton, 75012, Paris

Team leader :
Aziz El Amraoui
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Key words : #Audition #équilibre #surdité #cécité #Vieillissement #organes #sens #interactions #gène #environnement #thérapie #génique #Hearing #balance #deafness #lindness #aging #sensory #organs #gene #environment #interactions #gene #therapy