Team research topics:

The objective our team is to understand how the brain perceives and analyzes complex sounds. Sound processing begins in the ear, where the cochlea breaks down complex sounds into their elementary frequencies. How these frequencies are represented in the brain is a key question in the field of hearing, and in neurosciences in general. We control signals sent by the cochlea to the brain, by stimulating the sensory cells with light.

We are developing 2 complementary approaches:

1. we use optical methods to finely controls the optogenetic stimulation by coupling two-photon stimulation with holographic methods and fast temporal modulation, and w
2. e teamed up with experts in nanoelectronics to develop a new type of cochlear implant based on a grid of light sources.

This extremely precise control of the cochlear output will enable us to perform systematic studies to determine the information necessary and sufficient for sound identification.

 

Main techniques used:

Optical development including 2 and 3 photon microscopy and holography techniques, Optogenetics using precise spatiotemporal patterns, Membrane potential imaging, Large-scale electrophysiological recordings (Neuropixels), Neural coding and decoding using machine learning, Modelling and artificial intelligence

Address :
63 rue de Charenton, 75012, Paris

Team leader :
Jérémie Barral
Name of co-team leader :

Administrative Contact Name :


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Key words : #Système #auditif #code #neural #mécanique #cochléaire #optogénétique #Auditory #system #neural #code #cochlear #mechanics #optogenetics