L'Institut du Fer à Moulin organise deux conférences : 

The Institut du Fer à Moulin is organising two conferences:

Thursday 16 May 2024 at the Institut du Fer à Moulin: Lecture by Jesse Veenvliet from the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany on the theme: "Connecting scales and spaces in stembryos "Tuesday 16 July 2024 at the Institut du Fer à Moulin: Lecture by Jianping Fu from Biomedical Engineering, Cell & Developmental Biology, University of Michigan, Ann Arbo on the theme "Bioengineering Human Embryo and Organ Models".

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• Jeudi 16 mai 2024 à l'Institut du Fer à Moulin : Conférence de Jesse Veenvliet du Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany sur le thème : "Connecting scales and spaces in stembryos"
• Mardi 16 juillet 2024 à l'Institut du Fer à Moulin : Conférence de Jianping Fu du Biomedical Engineering, Cell & Developmental Biology, University of Michigan, Ann Arbo sur le thème "Bioengineering Human Embryo and Organ Models"

Early human development remains mysterious and difficult to study. Recent advances in developmental biology, stem cell biology and bioengineering have contributed to a significant interest in constructing controllable, stem cell-based models of human embryo and organs (embryoids / organoids). The controllability and reproducibility of these human development models, coupled with the ease of genetically modifying stem cell lines, the ability to manipulate culture conditions and the simplicity of live imaging, make them robust and attractive systems to disentangle cellular behaviors and signaling interactions that drive human development. In this talk, I will describe our effort in using human pluripotent stem cells (hPSCs) and bioengineering tools to develop controllable models of the peri-implantation embryonic development and early neural development. The peri-implantation human embryoids recapitulate early post-implantation developmental landmarks, including amniotic cavity formation, amniotic ectoderm-epiblast patterning, primordial germ cell specification, development and organization of embryonic germ layers, yolk sac formation, and primitive hematopoiesis. I will further discuss an hPSC-based, microfluidic neural tube-like structure (or µNTLS), whose development recapitulates some critical aspects of neural patterning in both brain and spinal cord regions and along both rostrocaudal and dorsoventral axes. The µNTLS is further utilized for studying development of different neuronal lineages, revealing pre-patterning of axial identities of neural crest progenitors and a role of neuromesodermal progenitors in spinal cord and trunk neural crest development. We have further developed dorsoventral patterned, microfluidic forebrain-like structures (µFBLS) with spatially segregated dorsal and ventral regions and layered apicobasal cellular organizations that mimic human embryonic brain development in pallium and subpallium areas, respectively. Together, both µNTLS and µFBLS offer 3D lumenal tissue architectures with an in vivo-like spatiotemporal cell differentiation and organization, useful for studying human neurodevelopment and disease.